Two sample MR report
ADK_Monocyte (Mono) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.0179013 | 0.0467515 | 0.7273107 |
| Weighted median | 5 | -0.0190423 | 0.0090383 | 0.0351302 |
| Inverse variance weighted | 5 | -0.0205805 | 0.0074479 | 0.0057225 |
| Simple mode | 5 | -0.0161456 | 0.0110610 | 0.2181501 |
| Weighted mode | 5 | -0.0165926 | 0.0117962 | 0.2322797 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.4603173 | 3 | 0.9275189 |
| Inverse variance weighted | 0.4636869 | 4 | 0.9769384 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0026601 | 0.0458248 | 0.9573603 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 8.85e-05 | 0 | TRUE | 0.3719622 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
